The clinical profile and outcomes of drug resistant tuberculosis in Central Province of Zambia

Drug Resistant Tuberculosis (DR-TB) is a significant public health and economic problem globally, affecting individuals in economically productive years and hindering workforce growth. A study in Zambia found that DR-TB prevalence in the Central Province was 1.4%, with 63.9% of affected adults aged 26-45 years. The majority of patients were from Kabwe District, with 89.6% having RR-TB and 6.2% having MDR-TB. Outcomes showed that 16.9% of patients were declared cured, 45.9% completed treatment, 6% lost to follow-up, and 21.3% died. Risk factors for mortality included age and male gender. The study recommends measures to improve surveillance, early detection, treatment initiation, and patient follow-up.