Prophages are Infrequently Associated With Antibiotic Resistance in Pseudomonasaeruginosa Clinical Isolates

A study on 187 clinical isolates of Pseudomonas aeruginosa in patients with cystic fibrosis (CF) found that lysogenic phages, which can integrate their genome into the bacterial chromosome, are infrequently associated with antimicrobial resistance (AMR). The study found no significant association between the number of prophages per isolate and the mean inhibitory concentration for any of the five anti-pseudomonal antibiotics. The findings suggest that prophages are not directly encoded on prophage sequences.