Phage therapy combats pandrug-resistant Acinetobacter baumannii infection safely and efficiently

This study investigates the effectiveness of phage therapy against A. baumannii strains with KL160 CPS, including pan-drug resistant A. baumannii YQ4. The lytic phage, ФAb4B, effectively inhibited biofilm formation and eradicated mature biofilms without cytotoxic or hemolytic effects. Phage therapy improved neutrophil counts, outperforming ciprofloxacin. Combinatorial treatment of phage-CIP saved 91% of mice, independent of dosage. Bacterial resistance was not a contributing factor to treatment failure.