Genomic insights into the dynamic antibiotic resistance landscape of Vibrio cholerae during the Cholera outbreak 2022 in Odisha, India

The research examines the dynamics of antibiogram trends, antibiotic resistance genes, and antibiotic efficacy against Vibrio cholerae strains during the 2022 cholera outbreak in Odisha, India. Eighty strains were analyzed for genotypic variations and MIC gradient analysis. Elevated resistances were observed against doxycycline, azithromycin, ciprofloxacin, and chloramphenicol. The study suggests alternative strategies like OCV, rehydration therapy, probiotics, and WASH interventions as effective tools to combat cholera outbreaks and mitigate antibiotic resistance.