Fast and Accurate Prediction of Antibiotic Susceptibility in Clinical Methicillin-Resistant S. aureus Isolates Using ATR-FTIR Spectroscopy: A Model Validation Study
A study presents an innovative approach using attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy for rapid antimicrobial resistance (AMR) assessment. The method distinguishes between methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA). The researchers observed early markers of effective antibiotic action in MSSA, which were absent in MRSA strains. They developed predictive models using ML-based modeling, achieving 100% consistency with minimum inhibitory concentration classification. This study highlights the potential of ATR-FTIR spectroscopy for rapid and accurate AMR assessment.
OUR UNDERWRITERS
Unrestricted financial support by:
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Antimicrobial Resistance Fighter Coalition |
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Bangalore Bioinnovation Centre |
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INTERNATIONAL FEDERATION PHARMACEUTICAL MANUFACTURERS & ASSOCIATIONS |
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BD |
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