Evolving antimicrobial resistance of extensively drug-resistant Gram-negative severe infections associated with conflict wounds in Ukraine: an observational study

A study in Ukraine investigated extensively drug-resistant (XDR) Gram negative phenotypes and genotypes following conflict-associated wounds. The research involved 100 isolates and found that resistance rates were higher in infections arising later in the patient pathway. Prevalent resistance genes included NDM + OXA-48-like, NDM-only, and KPC. The study highlights the importance of early screening for mechanisms of resistance in this setting, as early detection of carbapenemase genes amid XDR Gram negative phenotypes is crucial.