Antimicrobial resistance prediction by clinical metagenomics in pediatric severe pneumonia patients

A study evaluated the performance of Metagenomic Next-Generation Sequencing (mNGS) in predicting Antimicrobial Resistance (AMR) in pediatric patients with severe pneumonia. The study found that mNGS detected bacterial in 71.7% cases, with a sensitivity of 96.6% and specificity of 51.6%. It also showed a high sensitivity of 94.74% in predicting carbapenem resistance in Acinetobacter baumannii. The study suggests that mNGS could be a supplementary tool to conventional Phenotypic susceptibility testing (PST), but cannot replace conventional PST.