Antimicrobial resistance genes and associated mobile genetic elements in Escherichia coli from human, animal and environment

Antimicrobial resistance (AMR) is a global threat, with the environment playing a crucial role in its transmission. A study retrieved 2199 E. coli whole genome sequences from humans, animals, birds, and the environment to investigate ARG prevalence and genetic framework. The study found that the most prevalent ARGs were in the UK and USA, with IS-associated ARGs most prevalent in bird hosts. The study suggests strategies to combat AMR by predicting and addressing future resistance determinants.