Unseen Enemy: Mechanisms of Multidrug Antimicrobial Resistance in Gram-Negative ESKAPE Pathogens
Multidrug antimicrobial resistance (AMR) is a significant challenge in treating infectious diseases, particularly gram-negative Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. This review examines the mechanisms driving AMR in these bacteria, including drug uptake limitations, antibiotic-degrading enzyme production, drug target site changes, and enhanced efflux systems.
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