Antimicrobial resistance-attributable mortality: a patient-level analysis

A retrospective study in a UK teaching hospital found that 11.7% of all deaths were due to infection, with 4.2% being AMR-attributable. The majority of AMR-attributable deaths were associated with intrinsic resistance mechanisms, primarily by Enterococcus faecium, Enterobacterales carrying repressed chromosomal ampicillinase Cs (AmpCs), and Pseudomonas aeruginosa. A minority had acquired resistance mechanisms, primarily derepressed chromosomal AmpCs and ESBLs. Only 62.5% of AMR-attributable deaths had infection recorded on the death certificate.