Epidemiological and Genomic Analysis revealed the Significant Role of flies in Dissemination of Carbapenem-Resistant Enterobacteriaceae (CRE) in China

A study in China found high carriage rates of carbapenem-resistant Enterobacteriaceae (CRE) in flies, with 27.0% in AFs and 15.3% in human communities (HCs). Providencia spp. and Escherichia coli were predominant, with 90.6% due to the blaNDM gene. Phylogenetic tree analysis revealed frequent clonal transmission events. Environmental factors like precipitation and temperature influenced CRE prevalence in AFs flies, while total meat production in HCs positively correlated with CRE prevalence. Urgent interventions are needed to address this pressing issue.