Deep sequencing of Escherichia coli exposes colonisation diversity and impact of antibiotics in Punjab, Pakistan

  22 June 2024

A study in Pakistan found that the genetic diversity of multi-drug resistant E. coli in local populations is limited. The study involved collecting samples from outpatients and community dwellers, revealing a significant genetic diversity in gut colonisation. The Punjabi population had a different distribution of genetic lineages and AMR determinants compared to high-income countries. The study suggests longitudinal genomics-based surveillance is crucial for understanding the interplay between ecology and evolution in E. coli maintenance and dissemination.

Further reading: Nature Communications
Author(s): Tamim Khawaja et al
Effective Surveillance  
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