Antimicrobial resistance prediction by clinical metagenomics in pediatric severe pneumonia patients

  17 April 2024

A study evaluated the performance of Metagenomic Next-Generation Sequencing (mNGS) in predicting Antimicrobial Resistance (AMR) in pediatric patients with severe pneumonia. The study found that mNGS detected bacterial in 71.7% cases, with a sensitivity of 96.6% and specificity of 51.6%. It also showed a high sensitivity of 94.74% in predicting carbapenem resistance in Acinetobacter baumannii. The study suggests that mNGS could be a supplementary tool to conventional Phenotypic susceptibility testing (PST), but cannot replace conventional PST.

Author(s): Mingyu Gan et al
Effective Surveillance   Kids and Carers  
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