Antimicrobial sensitisers: Gatekeepers to avoid the development of multidrug-resistant bacteria

Multidrug-resistant bacteria’s resistance to antibiotics necessitates the development of new antibacterial agents, but high costs and timeframes limit their development. The concept of “antibiotic adjuvant” has limited drug development speed. This review article introduces the concept of non-self-antimicrobial sensitisers (NSAS), distinguishing it from antibiotic adjuvants. It discusses scientific methods to restore bacterial sensitivity to antibiotics, sources, and action mechanisms of existing NSAS, guiding further research.