Phage based therapies for Brucellosis in cattle to mitigate antimicrobial resistance

Researchers have isolated Brucellaphage Ludhiana (BpL) and used it for phage-based therapies of Brucellosis in cattle. They found that phage therapy initially stimulates immune responses, which decline slowly after 45 days. Live attenuated B. abortus vaccine strain S19 organisms were used to deliver a lytic Brucellaphage, causing high titers of anti-Brucella antibodies. The study also demonstrated the successful therapy of bovine Brucellosis using phage lysates of RB51 and S19.