Resistance pattern and maternal knowledge, attitude and practices of suspected Diarrheagenic Escherichia coli among children under 5 years of age in Addis Ababa, Ethiopia: cross sectional study
Suspected diarrheagenic E. coli (DEC) were isolated from 24.1% of stool samples. Among patients who had suspected diarrheagenic E. coli infections, the resistance rates were high for ampicillin (83.6%), augmentin (83.6%), trimethoprim-sulfamethoxazole (62.3%), and medium for chloramphenicol (21.3%), nalidixic acid (19.7%), and gentamicin (11.5%). Low levels of resistance were observed against ciprofloxacin (4.9%) and ceftriaxone (3.3%) (Table 2).
Table 2
Antimicrobial susceptibility patterns of E. coli isolates among children under five years of age at the selected public health institutions in Addis Ababa, Ethiopia, 2015
|
Enteropathogen (n) |
Interpretation |
Antibiotics |
|||||||
|---|---|---|---|---|---|---|---|---|---|
|
Amp |
Aug |
SXT |
C |
CIP |
Gen |
Na |
CRO |
||
|
Suspected Diarrheagenic E. coli(61) |
S (%) |
11.5 |
9.8 |
36.1 |
72.1 |
93.4 |
63.9 |
73.8 |
96.7 |
|
I (%) |
4.9 |
6.6 |
1.6 |
6.6 |
1.6 |
24.6 |
6.6 |
0 |
|
|
R (%) |
83.6 |
83.6 |
62.3 |
21.3 |
4.9 |
11.5 |
19.7 |
3.3 |
|
Antimicrobial resistance to one or more antibiotics was very high among the suspected diarrheagenic E. coli species isolated in the study (83.6%). Multiple resistances (resistance for two or more commonly used antibiotics) were observed in 85.2% of the DEC species isolated. One of the isolated strains of suspected diarrheagenic E. coli was resistant for seven antibiotics. Furthermore, susceptibility to all eight antibiotics tested was observed for 3 (4.9%) of the isolates.
Further reading: Antimicrobial Resistance and Infection Control
Effective Surveillance