A Multicenter Evaluation of the US Prevalence and Regional Variation in Macrolide-resistant S. pneumoniae in Ambulatory and Hospitalized Adult Patients in the US

Macrolide resistance was found in 39.5% of 3626 non duplicate Streptococcus pneumoniae isolates from adult ambulatory and inpatient settings at 329 US hospitals (2018-2019). Macrolide resistance was significantly higher for respiratory vs blood isolates and ambulatory vs inpatient admissions. Despite geographic variation, S. pneumoniae-macrolide resistance was >25% in most regions.